The Metabolism of Drugs by Hepatic Tumors*
نویسندگان
چکیده
Transformation from normal hepatic cell to tumor cell may be accompanied by a loss of ability to metabolize certain drugs by enzymes in the microsomal fraction. This change did not occur to any measurable extent during the "precancerous" stage; nor was it present in hepatic cells adjacent to the DAB-induced tumor. Only the neoplastic cell has lost this function--even severely damaged hepatic cells retained normal levels of metabolism of the drugs used in our experiments. The loss of enzyme activity in DAB-induced tumors was probably caused by an actual deficit of enzyme protein and not by a cofactor deficiency or by the presence of inhibitors in such tumors. Animals bearing hepatic tumors may be more "sensitive" than normal animals to some drugs. We have shown some tumor-bearing animals sleep longer after hexobarbital administration. Possible therapeutic implications are mentioned.
منابع مشابه
Minimally Invasive Swine Experimental Model for the In Vivo Study of Liver Metabolism of Drugs
PURPOSE To develop a clinically relevant porcine model for the study of hepatic metabolism of drugs by means of hepatic vein catheterization. MATERIALS AND METHODS review of literature and elaboration of a hypothesis, design of an experimental method. RESULTS recent clinical studies were conducted by withdrawing cirrhotic patients' blood from right hepatic vein during hepatic vein pressure ...
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